Clifford Earl
- Plain Clothes Sergeant
John Eastham
- Barman
Steve Eastin
- Sheriff Mazeroski
Rodney Eastman
- Ronald Purnell
Scott Eberlein
- Black-Haired Man
Mark Eden
- Ross
Ashley Edner
- Michelle Crittendon
Glynn Edwards
- Alfred Cole
Jeillo Edwards
- West Indian Woman
Monique Edwards
- Head Teller
Aeryk Egan
- Camera Dude [David Winkle's brother]
Michael Eklund
- FIO Clerk [Freedom of Information Office]
- Mr E Meats Mascot [Weiner Man]
Ahmed el-Shenawi
- Bodyguard
Sandor Elès
- Kreiber
Lovie Eli
- Second Singer
Beverley Elliott
- Raven
Devlin Elliott
- Pizza Delivery Man
Jack Elliott
- Marksman
Chris Ellis
- Sheriff Lance Heads
Frank Ellis
- Second Man
Greg Ellis
- Third British Crewman
Tracey Ellis
- Lucy Householder
- Audrey Pauley
Christopher Ellison
- CI5 Agent Biggs
- Paul Coogan
Tracy Elofson
- Four-Faced Man [The Seraphim]
Michael Elphick
- Sergeant Garbett
Cary Elwes
- Assistant Director Brad Follmer
Michael Emerson
- Oliver Martin [Anthony Fogelman]
Heather Emmanuelle
Daniel Emmett
- Cameraman
The Enigma
- The Conundrum
Bradford English
- Detective Yale Abbott
Glenn Ennis
- Bartender
Michael Ensign
- Dr Barnes
Derek Ensor
- Bank Manager
R Lee Ermey
- Reverend Findley
Frank Ertl
- Elder
Norman Eshley
- Jimmy Keller
Christine Estabrook
- Agent Henderson
Graeme Eton
- CI5 Mechanic
Christopher Ettridge
- Second Interrogator
Art Evans
- Argyle Saperstein
Kurt Evans
- Todd [Sports Store Employee]
Martin Evans
- Factotum
- Major Domo
- Dr Hartman
Solomon Eversol
- Ricky Koehler [Sketch Artist]
Lesley Ewen
- Receptionist
- First Agent
- Carina Maywald
- Renee Davenport